Preformulation studies of two naturally occurring compounds, sulforaphane and myricetin, are presented. Both compounds have shown promise as chemoprevention agents throughout the literature. Despite this evidence, minimal information is available to guide the progression of formulations designed for future drug development. The presented work describes solubility, stability, and solid-state characterization of these compounds. Additionally, a mathematical model based on the ideal solubility equation, which reasonably estimates the solubility of a hydrate is described. This model accounts for the dehydration energetics of the solute as it transforms from hydrate to anhydrous prior to melting and conversion to a hypothetical super-cooled liquid (HSL). This model will lend itself to the appreciation of the solubility differences that can exist between hydrate and anhydrous drug forms. By improving the accuracy of solubility estimation, drug development studies involving hydrates can be designed more accurately.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/556882 |
| Date | January 2015 |
| Creators | Franklin, Stephen J. |
| Contributors | Myrdal, Paul B., Myrdal, Paul B., Mansour, Heidi, Mayersohn, Michael, Yalkowsky, Samuel H. |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Electronic Dissertation |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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