Class of 2006 Abstract / Background: Approximately 2% of the population has hypothyroidism, and are treated with a levothyroxine product.
Unlike other medications, levothyroxine products have not been considered substitutable due to their narrow therapeutic window.
Objectives: To compare the bioequivalence study findings from studies conducted by the manufacturer of Synthroid to those conducted by other investigators.
Methods: Studies comparing levothyroxine product bioequivalence were found and divided according to time period, study design, and major funding party.
Results: Ten studies excluded due to a change in Synthroid formulation. Six steady state studies and 3 single dose studies were left.
Conclusions: Although data suggests bioequivalence between all studied levothyroxine products, there was not enough data to make a conclusion.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/624663 |
| Date | January 2006 |
| Creators | Bersbach, Brian |
| Contributors | Slack, Marion, College of Pharmacy, The University of Arizona |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Electronic Report |
| Rights | Copyright © is held by the author. |
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