Objective: To examine whether weight history and weight transitions over adult lifespan contribute to physical impairment among postmenopausal women. Design: BMI categories were calculated among postmenopausal women who reported their weight and height at age 18 years. Multiple-variable logistic regression was used to determine the association between BMI at age 18 years and BMI transitions over adulthood on severe physical impairment (SPI), defined as scoring <60 on the Physical Functioning subscale of the Rand thirty-six-item Short-Form Health Survey. Setting: Participants were part of the Women's Health Initiative Observational Study (WHI OS), where participants' health was followed over time via questionnaires and clinical assessments. Subjects: Postmenopausal women (n 76 016; mean age 635 (sd 73) years). Results: Women with overweight (BMI=250-299 kg/m(2)) or obesity (BMI = 300 kg/m(2)) at 18 years had greater odds (OR (95 % CI)) of SPI (151 (135, 169) and 214 (172, 265), respectively) than normal-weight (BMI=185-249 kg/m(2)) counterparts. Transitions from normal weight to overweight/obese or to underweight (BMI<185 kg/m(2)) were associated with greater odds of SPI (197 (184, 211) and 135 (106, 171), respectively) compared with weight stability. Shifting from underweight to overweight/obese also had increased odds of SPI (152 (111, 209)). Overweight/obese to normal BMI transitions resulted in a reduced SPI odds (052 (039, 071)). Conclusions: Higher weight history and transitions into higher weight classes were associated with higher likelihood of SPI, while transitioning into lower weight classes for those with overweight/obesity was protective among postmenopausal women.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/626012 |
| Date | 08 June 2016 |
| Creators | Wanigatunga, Amal A, Sourdet, Sandrine S, LaMonte, Michael J, Waring, Molly E, Nassir, Rami, Garcia, Lorena, Bea, Jennifer W, Seguin, Rebecca A, Ockene, Judith K, Sarto, Gloria E, Stefanick, Marcia L, Limacher, Marian, Manini, Todd M |
| Contributors | Univ Arizona, Dept Nutr Sci |
| Publisher | CAMBRIDGE UNIV PRESS |
| Source Sets | University of Arizona |
| Language | English |
| Detected Language | English |
| Type | Article |
| Rights | COPYRIGHT: © The Authors 2016 |
| Relation | http://www.journals.cambridge.org/abstract_S1368980016001415 |
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