abstract: Single molecules in a tunnel junction can now be interrogated reliably using chemically-functionalized electrodes. Monitoring stochastic bonding fluctuations between a ligand bound to one electrode and its target bound to a second electrode ("tethered molecule-pair" configuration) gives insight into the nature of the intermolecular bonding at a single molecule-pair level, and defines the requirements for reproducible tunneling data. Importantly, at large tunnel gaps, there exists a regime for many molecules in which the tunneling is influenced more by the chemical identity of the molecules than by variability in the molecule-metal contact. Functionalizing a pair of electrodes with recognition reagents (the "free analyte" configuration) can generate a distinct tunneling signal when an analyte molecule is trapped in the gap. This opens up a new interface between chemistry and electronics with immediate implications for rapid sequencing of single DNA molecules. / Dissertation/Thesis / Ph.D. Physics 2012
| Identifer | oai:union.ndltd.org:asu.edu/item:15007 |
| Date | January 2012 |
| Contributors | Chang, Shuai (Author), Lindsay, Stuart (Advisor), Ros, Robert (Committee member), Zhang, Peiming (Committee member), Tao, Nongjian (Committee member), Shumway, John (Committee member), Arizona State University (Publisher) |
| Source Sets | Arizona State University |
| Language | English |
| Detected Language | English |
| Type | Doctoral Dissertation |
| Format | 143 pages |
| Rights | http://rightsstatements.org/vocab/InC/1.0/, All Rights Reserved |
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