An approach to the total synthesis of novel opiate and Amaryllidaceae alkaloids is described. A rapid and efficient construction of the key intermediate [1.83], employing a palladium mediated cyclisation is presented. Studies towards the opiate ring skeleton utilising both nitrone and nitrile oxide [3+2] cycloadditions is investigated. Synthesis of the Amaryllidaceae alkaloids ring structure is described, involving a novel sublimation cyclisation protocol. The total synthesis of N, O-dimethyl norsanguinine is presented.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:285763 |
| Date | January 1999 |
| Creators | Harvey, Darren |
| Publisher | University of Sussex |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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