Certain membrane bound mucins such as MUC1, MUC4, and MUC12 were expressed in normal bladder urothelium. MUC1 expression was the highest in normal bladder urothelium and was present in almost all samples. In superficial bladder cancer, MUC1 demonstrated a pattern of expression that increased in proportion to the increase in tumour grade from Grade 1 to Grade 3 and carcinoma <i>in situ</i>. Utilising TMAs, membrane-bound mucins such as MUC1, <i>MUC3, </i>MUC4, MUC12 and MUC 16 were shown to have increased incidence of expression with tumour stage progression to muscle-invasive bladder cancer (stage T2 and above). Secretory mucins showed a more varied pattern of expression. <i>MUC2</i> mRNA was up-regulated in progressive muscle-invasive bladder cancer. MUC5AC and MUC5B displayed a low incidence of expression in superficial tumours and muscle invasive bladder cancer. <i>MUC7</i> mRNA expression, however, was limited to only muscle-invasive disease similar to the membrane-bound mucins described above. In a small proportion of patients in the recurrent progressive TMA, expression of MUC4, MUC5AC and <i>MUC</i>5B in penultimate superficial tumours prior to tumour progression allowed prediction of impending disease progression to muscle invasive disease. MUC5B, MUC12 and MUC13 were expressed at higher incidence in the single non-recurrent TMA, compared with the incidence of expression in the recurrent non-progressive TMA. The expression of these mucins in newly diagnosed superficial bladder tumours may thus favour better prognosis, with a subsequent reduced risk of tumour recurrence.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:440597 |
| Date | January 2006 |
| Creators | Yong, Sze Ming |
| Publisher | University of Aberdeen |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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