The survival motor neuron (SMN) complex is a macromolecular structure composed of SMN, Gemin2-8 and Unrip. The best-documented function of the SMN complex concerns the assembly of the spliceosome building blocks, uridine-rich small nuclear ribonucleoproteins (UsnRNPs). SMN deficiency results in Spinal Muscular Atrophy, a disorder characterised by degeneration of spinal cord motor neurons and progressive muscular weakness.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:489418 |
| Date | January 2008 |
| Creators | Cauchi, Ruben J. |
| Publisher | University of Oxford |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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