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The actions of a soft coral derived natural product on neurones

The effects of a soft coral derived product and its major active component, 3-carboxyl-methylpyridinium (CMP), were assessed in cultured neurones from dorsal root ganglion (DRG) and the hippocampus, and in hippocampal slices. Application of the soft coral preparation or CMP to cultured DRG neurones reduced an outward potassium current, causing attenuation of spike frequency adaptation. This evoked a switch to multiple firing in previously single firing DRG neurones.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493403
Date January 2008
CreatorsWoolley, David
PublisherUniversity of Aberdeen
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Sourcehttp://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=24801

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