Type Vll collagen (ColVII) is the main component of anchoring fibrils, structures within the lamina densa of the basement membrane responsible for dermal-epidermal adherence in skin. Mutations in the human ColVll gene, C0L7A1, cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae associated with a greatly increased risk of skin cancer. The aim of this study was to investigate the effect of loss of ColVII on cutaneous SCC behaviour using RNAi.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:497913 |
| Date | January 2008 |
| Creators | Martins, Vera Lisa Coelho |
| Publisher | Queen Mary, University of London |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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