Background: Sepsis may be modelled in vivo using lipopolysaccharide (LPS) to cause microvascular disturbances including macromolecular leak and leucocyte adhesion. Such changes may be due to an altered balance of eNOS and iNOS. Statins are widely used to lower cholesterol. Recently evidence indicates statins may exert pleiotropic effects, possibly restoring physiological levels of eNOS and iNOS.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:505784 |
| Date | January 2009 |
| Creators | McGown, Caroline Christina |
| Publisher | University of Sheffield |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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