Tumour escapes from immunosurvillence though tumour-mediated suppression. Tumour disrupts dendritic cells (DC) and macrophage functions and interferes with developing anti-tumour microenvironment. Indeed, DC dysfunction in cancer is a limiting factor in cancer immunotherapy. The hypothesis that alternation of DC MAPK pathway is a strategy by which tumours evade immunosurvillence was tested. Our results revealed that, tumours exploit DC through manipulation of ERK signalling pathway which resulting in inhibition of IL-12 production. In addition, tumours suppress the fibroblasts induced IL-23 production by DC. Through Interfering with IL- 12 and IL-23 production, tumours down regulate immediate inflammatory response responsible for defending against the newly developed malignancy. Similarly, our results on monocyte/ macrophage lineage showed that tumour alternate their function away from pro-inflammatory activity and closer to the regulatory profile.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:606810 |
| Date | January 2013 |
| Creators | El Refaee, Mohamed |
| Publisher | University of Nottingham |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
Page generated in 0.0018 seconds