Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics. In streptomycetes a gene encoding for a putative Sco-like protein has been identified and is part of an operon that contains two other genes predicted to handle cellular copper. This thesis reports first on the Sco-like protein from Streptomyces lividans (Sco sl) and presents a series of experiments that firmly establish a role for Sco sl as a copper metallochaperone as opposed to a role as a thiol-disulfide oxidoreductase that has been assigned to other bacterial Sco proteins.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:635891 |
| Date | January 2014 |
| Creators | Blundell, Katie Laura Irene May |
| Publisher | University of Essex |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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