Glass-ionomer-cements (GIC) have been shown to act as matrices for the slow release of fluoride ions. The aim of the current research is to assess whether the incorporation of differing species leads to a similar release pattern. In this study, the objective is to attempt to clarify the release mechanism within the cement. GICs evaluated had differing glass compositions all glasses having Si Al Ca and O present. AH2 has additionally Na, F and P, MP4 had additionally Na, LG26 had additionally F and P and LG30 P only. The influence of different ions on the binding and release characteristics of the cement were evaluated. This study investigated the use of four different experimental GICs as carriers for the release of chlorhexidine acetate (CHA) and amprolium hydrochloride (AHCI) at included concentrations ranging from 0.5% to 13.0% of added species by weight. Release into water at 37 °C was examined using high-performance liquid chromatography (HPLC). Physical properties evaluated included compressive strengths, and working times and setting times. In general, the more added species that was included, the greater the amount released. More amprolium hydrochloride was released and at a faster rate than chlorhexidine acetate. For most GICs, compressive strengths were found to be decreased by the presence of an additional species, while working and setting times increased. Amprolium hydrochloride had a more marked effect than chlorhexidine acetate. The effects of included species on the surfaces of the GICs were observed by Scanning Electron Microscopy. The influences of the additional species on the chemical setting of the GICs were measured by spectroscopic methods including FTIR.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:639509 |
| Date | January 2007 |
| Creators | Palmer, G. |
| Publisher | University College London (University of London) |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://discovery.ucl.ac.uk/1445063/ |
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