Following DFT calculations, the structure of a new, remotely stabilised, N-heterocyclic carbene, thought to be very strongly a-donating, was proposed. This structure was benzo[c]quinolizin-6-ylidene. Synthesis of the basic scaffold of the benzo[c]quinolizine ring system was performed, giving benzo[c]quinolizin-6-one (2.3a). Several novel 5 and 7 substituted varieties (2.3b-e) were also synthesised, requiring the development of a new route, due to the failure of the initial coupling step when using substituted substrates.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:653076 |
| Date | January 2014 |
| Creators | Murphy, Elliot Anthony |
| Publisher | University of Bristol |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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