Obesity is a major global and national problem with a variety of consequences and effects. The relationship of fetal programming with obesity has been discovered through both human and animal studies and it has been found that nutritional programming can predispose the developing offspring to obesity later in life. However, many aspects of this fetal programming have yet to be fully determined, for instance the environmental and metabolic factors involved. This thesis has investigated the programming effects of maternal low protein restriction (MLP) and maternal age (2 month, 4 month and 6-9 month old mothers) in the rat, looking at both immature (4 weeks old) and mature (9 months old) adult offspring. Postnatal high fat diets were fed for 9 weeks to exacerbate potential obesogenic effects. During the trials various measures were studied, body weight, feed intake, energy expenditure, metabolism, body composition, body fat distribution, activity and behaviour.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:659284 |
| Date | January 2014 |
| Creators | Ware, Samantha |
| Publisher | University of Nottingham |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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