Inflammatory diseases of the bowel and liver form an important part of my clinical work as a gastroenterologist. Absent or reduced clinical response to steroids is detrimental to patient outcome in these conditions. This thesis serves to investigate the correlation between in vitro and in vivo steroid response in these inflammatory diseases and to elaborate further on the intracellular mechanisms by which a patient may fail to respond clinically to steroids with particular emphasis on the role of IL-2 and its effect on the glucocorticoid receptor. A greater understanding of these mechanisms may allow the development of diagnostic techniques and targeted therapies to enhance glucocorticoid response in steroid resistant patents and thus improve clinical outcome
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:683463 |
| Date | January 2012 |
| Creators | Di Mambro, A. J. |
| Publisher | University of Bristol |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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