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The epidermal barrier in atopic disease

The prevalence of allergic diseases, including atopic dermatitis (AD; also known as atopic eczema), food allergy, hay fever, asthma, atopic eye disease and eosinophilic eosophagitis has increased dramatically in the developed world and in urbanised parts of the developing world over the past several decades. Atopic dermatitis is the most common chronic inflammatory disease of children, affecting 15-20% of children in the US and Europe. In many cases, infantile AD is associated with significant allergies to common foods such as peanut, hen’s egg and cow’s milk. Atopic dermatitis is followed in approximately 50% of cases by development of asthma and in 70%, hay fever in later childhood. The clustering of these conditions that often occurs in sequence has been termed the ‘atopic march’. The basis for the remarkable increase in the prevalence of these diseases is not well understood. For most of the latter half of the 20th Century the pathogenesis of atopic dermatitis was assumed to be primarily due to immune dysregulation. In the first decade of the 21st century, however, several lines of evidence emerged that placed the epithelial barrier as a central player in the pathogenesis of AD and of atopic disease in general. Several key discoveries that contributed to this change in understanding are included in the collection of publications presented for this DSc submission. The publications can be broadly grouped into studies on single gene disorders, their relevance to complex disease, subphenotyping of complex disease, mechanistic work and finally, some early translational approaches.
Date January 2016
CreatorsIrvine, Alan David
PublisherQueen's University Belfast
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation

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