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Humoral alloimmunity in cardiac allograft rejection

Although the short-term outcomes of solid allograft survival have improved substantially over the last few decades, there has been no significant improvement in long-term survival of solid allografts. This thesis presents the initial characterisation of alloantibody mediated rejection in a murine heart transplant model, with particular focus on the impact of the different phases of the humoral alloimmune response (follicular or germinal centre) on graft rejection.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:763835
Date January 2019
CreatorsAlsughayyir, Jawaher
ContributorsPettigrew, Gavin
PublisherUniversity of Cambridge
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Sourcehttps://www.repository.cam.ac.uk/handle/1810/286971

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