Dissertation (DScD) -- Boston University, Henry M. Goldman School of Dental Medicine, 2010 (Department of Periodontology and Oral Biology). / Diabetes and periodontal disease exhibit a bidirectional relationship centered on an enhanced
inflammatory response manifested both locally and systemically. The observation that
hyperglycemia by itself, in the absence of additional inflammatory signals, promotes a proinflammatory
environment indicates that diabetes is an independent risk factor for periodontal
disease. Leukocyte pre-activation or priming in diabetes has been demonstrated. Excessive ROS
release by leukocytes, upregulation of pro-inflammatory mediators and adhesion molecules are
characteristic to T2DM-associated low-grade inflammation. However, the mechanisms by which
chronic hyperglycemia leads to leukocyte activation are not fully understood. [TRUNCATED]
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/32698 |
| Date | January 2010 |
| Creators | Sima, Corneliu |
| Publisher | Boston University |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
| Rights | This work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author. |
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