Thesis (M.A.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / The low-density lipoprotein receptor-related protein (LRP) is a 4544 amino acid polypeptide with structural similarity to the low-density lipoprotein receptor. LRP contains two subunits, a 515kDa subunit and an 85kDa subunit. LRP is found in a wide range of tissues, although its main function is confined to the liver.
LRP is an Apo E binding receptor, which led to the idea that it might serve to clear chylomicron remnants and large Beta-VLDL from the plasma. The majority of research supports this hypothesis, although a small amount of conflicting data exists that will require further explanation.
LRP has also been implicated as a receptor for alpha2-macroglobulins, which are protease inhibitors present in the plasma. Therefore, it appears that LRP and the alpha2-macroglobulin receptor are the same molecule. / 2031-01-01
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/34650 |
| Date | January 1992 |
| Creators | Palmieri, Maria Lucia |
| Publisher | Boston University |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
Page generated in 0.0036 seconds