There are various novel approaches to cancer immunotherapy. These potential treatments for malignant cancers include the adoptive transfer of natural killer cells, T cell receptor T cells, chimeric antigen receptor T cells, and many more. It is important to note that conducting these revolutionizing treatments became possible due to the humanized mouse models, which provide the experimental base models for investigating anti-tumor research. To further enhance the measure of treatment for malignant cancers, it is vital to understand how the humanized mouse models work and represent the human immune microenvironment. Here, I review the history of the humanized mouse models, their variations and advantages and limitations that follow with the different types of models, their roles in evaluating the potential cancer immunotherapy treatments, and their anticipated roles in the future to further assist in developing a more personalized antitumor treatment.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/48283 |
| Date | 29 February 2024 |
| Creators | Kim, Tae Rang |
| Contributors | Crossland, Nicholas A., Qin, Yan |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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