by Sea Man Mei, Mandy. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1998. / Includes bibliographical references (leaves 203-214). / Abstract also in Chinese. / ACKNOWLEDGMENTS --- p.i / ABSTRACT --- p.ii / LIST OF ABBREVAIATIONS --- p.vi / TABLE OF CONTENTS --- p.vii / Chapter Chapter1 --- General Introduction / Chapter 1.1 --- DEFINITION --- p.2 / Chapter 1.2 --- MOTIVATION OF THE ONSET OF WEIGHT CYCLING --- p.3 / Chapter 1.3 --- PHYSIOLOGICAL EFFECTS OF WEIGHT CYCLING --- p.6 / Chapter 1.3.1 --- """Dieting-Induced Obesity"" Hypothesis" --- p.6 / Chapter 1.3.1.1 --- Food Efficiency --- p.6 / Chapter 1.3.1.2 --- Proposed Mechanisms for the Increase of Food Efficiency --- p.10 / Chapter 1.3.1.3 --- Change in Body Fat --- p.14 / Chapter 1.3.2 --- Association with Increased Mortality and Coronary Heart Disease (CHD) --- p.15 / Chapter Chapter2 --- Depletion of Linoleic Acid and α-Linolenic Acid Caused by Weight Cycling is Independent of the Extent of Calorie-Restriction / Chapter 2.1 --- INTRODUCTION --- p.18 / Chapter 2.1.1 --- Nomenclature of Fatty Acids --- p.18 / Chapter 2.1.2 --- Metabolism and Physiological Roles of LA and α-LnA --- p.19 / Chapter 2.1.2.1 --- "LA, α-LnA and their Derivatives as Structural Components" --- p.21 / Chapter 2.1.2.2 --- Production of Eicosanoids from LA and α-LnA --- p.22 / Chapter 2.1.2.3 --- Other Physiological Roles --- p.23 / Chapter 2.1.3 --- Dietary LA and α-LnA Relative to CHD --- p.24 / Chapter 2.1.3.1 --- Dietary LA and CHD --- p.24 / Chapter 2.1.3.2 --- Dietary α-LnA and CHD --- p.26 / Chapter 2.1.4 --- WC-Induced Alteration in the Composition of Tissue Lipids --- p.27 / Chapter 2.2 --- OBJECTIVE OF THE PRESENT STUDY --- p.29 / Chapter 2.3 --- MATERIALS AND METHODS --- p.30 / Chapter 2.3.1 --- Animals and Diets --- p.30 / Chapter 2.3.2 --- Lipid Analysis --- p.32 / Chapter 2.3.3 --- Triacylglycerol Species Analysis --- p.34 / Chapter 2.3.4 --- Other Assays --- p.35 / Chapter 2.3.5 --- Statistics --- p.35 / Chapter 2.4 --- RESULTS --- p.36 / Chapter 2.4.1 --- Food Intake --- p.36 / Chapter 2.4.2 --- Change of Body weight --- p.38 / Chapter 2.4.3 --- Weight of Liver and Adipose Tissues --- p.40 / Chapter 2.4.4 --- Serum Cholesterol and Triglycerides --- p.41 / Chapter 2.4.5 --- Carcass Total Fatty Acids --- p.42 / Chapter 2.4.6 --- Adipose Tissue Fatty Acids --- p.44 / Chapter 2.4.7 --- Liver Fatty Acids --- p.47 / Chapter 2.5 --- DISSCUSION --- p.50 / Chapter Chapter3 --- Influence of Dietary Fat Level on Fatty Acid Composition and Adiposity in Weight-Cycled Rats / Chapter 3.1 --- INTRODUCTION --- p.56 / Chapter 3.1.1 --- Fat Preference and Intake in Humans --- p.56 / Chapter 3.1.2 --- Alteration of Lipid Metabolism Induced by Dietary Fat --- p.58 / Chapter 3.1.3 --- Interaction Between Weight Cycling and Fat Intake --- p.60 / Chapter 3.2 --- OBJECTIVE OF THE PRESENT STUDY --- p.62 / Chapter 3.3 --- MATERIALS AND METHODS --- p.63 / Chapter 3.3.1 --- Animals and Diets --- p.63 / Chapter 3.3.2 --- Analysis of Adipocytes --- p.66 / Chapter 3.3.3 --- Fatty Acid Analysis --- p.67 / Chapter 3.3.4 --- "Determination of Serum Cholesterol, Triglycerides and Glucose" --- p.68 / Chapter 3.3.5 --- Statistics --- p.68 / Chapter 3.4 --- RESULTS --- p.69 / Chapter 3.4.1 --- Body Weight --- p.69 / Chapter 3.4.2 --- Food Intake and Food Efficiency --- p.71 / Chapter 3.4.3 --- Weight of Liver --- p.74 / Chapter 3.4.4 --- Weight of Adipose Tissue --- p.74 / Chapter 3.4.5 --- Number and Size of Adipocytes --- p.81 / Chapter 3.4.6 --- "Serum Triglycerides, Cholesterol and Glucose" --- p.85 / Chapter 3.4.7 --- Fatty Acid Composition --- p.92 / Chapter 3.5 --- DISCUSSION --- p.145 / Chapter 3.5.1 --- Weight Cycling-Induced Obesity Only with a High-Fat Diet --- p.145 / Chapter 3.5.1.2 --- Effect of Weight Cycling on the Size of Adipocytes --- p.147 / Chapter 3.5.1.3 --- Food Efficiency during Weight Cycling --- p.148 / Chapter 3.5.2 --- Weight-Cycling Induced Specific Alteration of Fatty Acid Metabolism --- p.149 / Chapter Chapter4 --- Weight Cycling Altered the Activities of Lipoprotein Lipase and Lipogenic Enzymes in Rats / Chapter 4.1 --- INTRODUCTION --- p.152 / Chapter 4.1.1 --- Fatty Acid Metabolism --- p.152 / Chapter 4.1.1.1 --- Fatty Acid Synthesis --- p.152 / Chapter 4.1.1.2 --- Fatty Acid Storage --- p.155 / Chapter 4.1.1.3 --- Fatty Acid Oxidation --- p.156 / Chapter 4.1.2 --- Hormonal Control of Fatty Acid Metabolism During Fasting and Refeeding --- p.158 / Chapter 4.1.2.1 --- Fatty Acid Metabolism During Fasting --- p.158 / Chapter 4.1.2.2 --- Fatty Acid Metabolism During Fed-State --- p.160 / Chapter 4.2 --- OBJECTIVE OF THE PRESENT STUDY --- p.161 / Chapter 4.3 --- MATERIALS AND METHODS --- p.162 / Chapter 4.3.1 --- Samples --- p.162 / Chapter 4.3.2 --- Enzymatic Analysis --- p.162 / Chapter 4.3.2.1 --- Lipoprotein Lipase (LPL; EC 3.1.1.34) --- p.162 / Chapter 4.3.2.2 --- Fatty Acid Synthase (FAS; EC 2.3.1.85) --- p.165 / Chapter 4.3.2.3 --- Malic Enzyme (ME; EC 1.1.1.40) --- p.166 / Chapter 4.3.2.4 --- Pyruvate Kinase (PK; EC 2.7.1.40) --- p.166 / Chapter 4.3.2.5 --- Acetyl-CoA Carboxylase (ACC; EC 6.4.1.2) --- p.167 / Chapter 4.3.2.6 --- "Phosphoenolpyruvate Carboxykinase (PEPCK, EC 4.1.1.32)" --- p.168 / Chapter 4.3.2.7 --- Determination of Protein Content --- p.169 / Chapter 4.3.3 --- Determination of Serum Insulin and Serum Glucagon --- p.169 / Chapter 4.3.4 --- Statistics --- p.169 / Chapter 4.4 --- RESULTS --- p.170 / Chapter 4.4.1 --- Enzymatic Analysis --- p.170 / Chapter 4.4.1.1 --- Lipoprotein Lipase --- p.170 / Chapter 4.4.1.2 --- Fatty Acid Synthase --- p.175 / Chapter 4.4.1.3 --- Malic Enzyme --- p.182 / Chapter 4.4.1.4 --- Pyruvate Kinase --- p.182 / Chapter 4.4.1.5 --- Acetyl-CoA Carboxylase --- p.187 / Chapter 4.4.1.6 --- Phosphoenolpyruvate Carboxykinase --- p.187 / Chapter 4.4.2 --- Level of Serum Insulin and Glucagon --- p.192 / Chapter 4.5 --- DISCUSSION --- p.196 / Chapter 4.5.1 --- Effect of Weight Cycling on Activity of Lipoprotein Lipase and Lipogenic Enzymes Activity --- p.196 / Chapter 4.5.2 --- The Overshoot of Enzymatic Activities in Relation to Tissue Fatty Acid Composition --- p.198 / Chapter 4.5.3 --- No Elevation of Plasma Insulin in Weight Cycled Rats --- p.199 / Chapter Chapter5 --- Conclusion --- p.200 / References --- p.203
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_322330 |
| Date | January 1998 |
| Contributors | Sea, Man Mei Mandy., Chinese University of Hong Kong Graduate School. Division of Biochemistry. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, ix, 214 leaves : ill. ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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