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Diagnostic markers for late-onset infection in very low birthweight infants.

Wong Pui On Raymond. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (leaves 105-120). / Abstracts in English and Chinese. / Contents --- p.i / Abstract --- p.vi / Statement of originality --- p.xii / Acknowledgments --- p.xiii / List of figures and tables --- p.xiv / Abbreviations --- p.xvii / Publications --- p.xx / Text / Chapter Chapter 1: --- Introduction and Objectives --- p.1 / Chapter 1.1 --- Neonatal Sepsis --- p.2 / Chapter 1.2 --- Markers of Infection --- p.4 / Chapter 1.2-1 --- Clinical markers for sepsis --- p.4 / Chapter 1.2-2 --- Cytokines as markers of sepsis --- p.7 / Chapter 1.2-3 --- Cell surface receptors as markers of sepsis --- p.8 / Chapter 1.3 --- The immune system in response to pathogen challenge --- p.10 / Chapter 1.3-1 --- Source of cytokines --- p.11 / Chapter 1.4 --- General outline of cytokines implicated in sepsis --- p.12 / Chapter 1.4-1 --- IL-2 --- p.13 / Chapter 1.4-2 --- IL-4 --- p.15 / Chapter 1.4-3 --- IL-5 --- p.16 / Chapter 1.4-4 --- IL-6 --- p.17 / Chapter 1.4-5 --- IL-10 --- p.18 / Chapter 1.4-6 --- IFN-γ --- p.19 / Chapter 1.4-7 --- TNF-α --- p.21 / Chapter 1.5 --- General outline of cell surface receptors implicated in sepsis --- p.23 / Chapter 1.5-1 --- CDllb --- p.23 / Chapter 1.5-2 --- CD64 --- p.24 / Chapter 1.5-3 --- CD45RO --- p.25 / Chapter 1.5-4 --- CD25 --- p.26 / Chapter 1.6 --- Aims of study --- p.27 / Chapter Chapter 2: --- Materials and methods --- p.31 / Chapter 2.1 --- Patients inclusion criteria and classification --- p.32 / Chapter 2.2 --- Sample collection and sepsis screening --- p.33 / Chapter 2.3 --- Quantitation of cell surface antigens --- p.35 / Chapter 2.3-1 --- Cell acquisition and calculation --- p.37 / Chapter 2.4 --- Quantitation of plasma cytokines --- p.38 / Chapter 2.4-1 --- Cytometric Beads Array assay --- p.40 / Chapter 2.5 --- Statistical Analysis --- p.41 / Chapter Chapter 3: --- "Cell surface and plasma cytokine markers for the diagnosis of late-onset sepsis in preterm, very low birthweight (VLBW) infants" --- p.51 / Chapter 3.1 --- Results --- p.52 / Chapter 3.1-1 --- Lymphocyte markers: CD25 and CD45RO --- p.52 / Chapter 3.1-2 --- Neutrophil markers --- p.53 / Chapter 3.1-2a --- CD64 --- p.54 / Chapter 3.1-2b --- CDllb --- p.55 / Chapter 3.1-3 --- Purified CDllb --- p.56 / Chapter 3.1-4 --- Comparison of cell surface markers --- p.56 / Chapter 3.1-5 --- Interluekin 6 (IL-6) and C-Reactive Protein (CRP) --- p.57 / Chapter 3.2 --- Combined analysis of diagnostic markers --- p.58 / Chapter 3.3 --- Discussion --- p.58 / Chapter Chapter 4: --- Proinflammatory and anti-inflammatory cytokine response in preterm very low birthweight infants (VLBW) with systemic infections --- p.82 / Chapter 4.1 --- Results --- p.83 / Chapter 4.1-1 --- Correlation of cytokine levels in infected patients --- p.84 / Chapter 4.2 --- Subgroup analysis --- p.85 / Chapter 4.2-1 --- Proinflammatory and anti-inflammatory cytokine ratios --- p.85 / Chapter 4.2.2 --- The deceased case --- p.86 / Chapter 4.3 --- Discussion --- p.87 / Chapter Chapter 5: --- General Discussion and Conclusions --- p.97 / Chapter 5.1 --- General Discussion --- p.98 / Chapter 5.1-1 --- Cell surface markers --- p.98 / Chapter 5.1-2 --- Infection markers with prognostic significance --- p.100 / Chapter 5.1-3 --- Limitations of infection markers in clinical applications --- p.100 / Chapter 5.2 --- Conclusions and future development --- p.102 / Chapter 5.2-1 --- Conclusions --- p.102 / Chapter 5.2-2 --- The future development --- p.102 / References --- p.105

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_324848
Date January 2004
ContributorsWong, Pui On Raymond., Chinese University of Hong Kong Graduate School. Division of Medical Sciences.
Source SetsThe Chinese University of Hong Kong
LanguageEnglish, Chinese
Detected LanguageEnglish
TypeText, bibliography
Formatprint, xx, 120 leaves : ill. (some col.) ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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