Because of the measuring instrument or the biological variability, many studies with survival data involve covariates which are subject to measurement error. In such cases, the naive estimates are usually biased. In this thesis, we propose a bias corrected estimate of the regression parameter for the multinomial probit regression model with covariate measurement error. Our method handles the case when the response variable is subject to interval censoring, a frequent occurrence in many medical and health studies where patients are followed periodically. A sandwich estimator for the variance is also proposed. Our procedure can be generalized to general measurement error distribution as long as the first four moments of the measurement error are known. The results of extensive simulations show that our approach is very effective in eliminating the bias when the measurement error is not too large relative to the error term of the regression model. / Censoring is an intrinsic part in survival analysis. In this thesis, we establish the asymptotic properties of MMLE to general transformation models when data is subject to right or left censoring. We show that MMLE is not only consistent and asymptotically normal, but also asymptotically efficient. Thus our asymptotic results give a definite answer to a long-term argument on the efficiency of the maximum marginal likelihood estimator. The difficulty in establishing these results comes from the fact that the score function derived from the marginal likelihood does not have ordinary independence or martingale structure. We will develop a discretization method in establishing our results. As a special case, our results imply the consistency, asymptotic normality and efficiency for the multinomial probit regression, a popular alternative to the Cox regression model. / General transformation model is an important family of semiparametric models in survival analysis which generalizes the linear transformation model. It not only includes typical Cox regression model, proportional odds model and multinomial probit regression model, but also includes heteroscedastic hazard regression model, general heteroscedastic rank regression model and frailty model. By maximizing the marginal likelihood, a parameter estimation (MMLE) can be obtained with the property that it avoids estimating the baseline survival function and censoring distribution, and such property is enjoyed by the Cox regression model. In this thesis, we study three areas of generalization of general transformation models: main response variable is subject to censoring, covariates are time-varying and covariates are subject to measurement error. / In medical studies, the covariates are not always the same during the whole period of study. Covariates may change at certain time points. For example, at the beginning, n patients accept drug A as treatment. After certain percentage of patients have died, the investigator might add new drug B to the rest of the patients. This corresponds to the case of time-varying covariates. In this thesis, we propose an estimation procedure for the parameters in general transformation model with this type of time-varying covariates. The results of extensive simulations show that our approach works well. / Wu, Yueqin. / Adviser: Ming Gao Gu. / Source: Dissertation Abstracts International, Volume: 70-06, Section: B, page: 3589. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2008. / Includes bibliographical references (leaves 74-78). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese. / School code: 1307.
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_344355 |
| Date | January 2008 |
| Contributors | Wu, Yueqin., Chinese University of Hong Kong Graduate School. Division of Statistics. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, theses |
| Format | electronic resource, microform, microfiche, 1 online resource (vii, 78 leaves : ill.) |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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