Intracavitary high-dose-rate brachytherapy (HDRBT) is a treatment option for
endometrial cancer, depending on the cancer stage. Because of the steep high dose gradient
of HDRBT, very small differences in the treatment plans, surrounding organ’s anatomy, or
procedures during the treatment could potentially cause significant dose variation to the
tumor, as well as organs at risks (OAR) nearby the treatment area, which could result in
unwanted radiobiological side effects. In this retrospective study, the radiobiological plan
evaluation parameters Equivalent Uniform Dose (EUD), Normal Tissue Complication
Probability (NTCP) are used as assessment tools to evaluate HDRBT plans. Furthermore,
gynecological applicator position in the coordinate system, and possible dose variations to
the tumor and critical organs from the initial fraction in comparison with subsequent
fractions over the entire multi fractionated treatment are studied. The evaluations were
performed for 118 HDR treatment plans for 30 patients by registration of the subsequent treatment plans into the initial CT-image guided plan. Dose fractionation regimens varied
from 4Gy to 7Gy per fraction, 1 or 2 fractions per week, depending on the cancer stage.
Our results demonstrate no significant radiobiological impacts on organs at risks (OAR).
In addition, the results of the applicator positions’ study indicate that improvement of
immobilization and localization devices are recommended. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_40954 |
| Contributors | Shojaei, Marjan (author), Pella, Silvia (Thesis advisor), Leventouri, Theodora (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Physics |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 61 p., application/pdf |
| Rights | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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