This research is part of a long-term project aimed at elucidating important structural
features, of both ligands and metals, that are needed to produce effective anti-cancer agents.
The specific goal is the synthesis of organotin polymers containing amino acids, in this
case the diamino acid diglycine. The desired materials were synthesized with percent yields
ranging from 32-99%. The products were synthesized employing the interfacial
polymerization technique. The polymers were then characterized utilizing the following
physical characterization techniques: light scattering photometry (LS), Infrared
spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and matrix assisted
laser desorption mass spectroscopy (MALDI). Physical characterization showed evidence
of formation of desired adducts in addition to data that was consistent with the formation
of materials containing multiple repeat units. The materials were then analyzed for
biological activity. The synthesized materials displayed the ability to inhibit tested cancer
cell lines. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_40955 |
| Contributors | Slawek, Paul Peter (author), Carraher, Charles E. (Thesis advisor), Haky, Jerome E. (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 120 p., application/pdf |
| Rights | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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