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Investigating the Categories for Cholesterol and Blood Pressure for Risk Assessment of Death Due to Coronary Heart Disease

Many characteristics for predicting death due to coronary heart disease are measured on a continuous scale. These characteristics, however, are often categorized for clinical use and to aid in treatment decisions. We would like to derive a systematic approach to determine the best categorizations of systolic blood pressure and cholesterol level for use in identifying individuals who are at high risk for death due to coronary heart disease and to compare these data derived categories to those in common usage. Whatever categories are chosen, they should allow physicians to accurately estimate the probability of survival from coronary heart disease until some time t. The best categories will be those that provide the most accurate prediction for an individual's risk of dying by t. The approach that will be used to determine these categories will be a version of Classification And Regression Trees that can be applied to censored survival data. The major goals of this dissertation are to obtain data-derived categories for risk assessment, compare these categories to the ones already recommended in the medical community, and to assess the performance of these categories in predicting survival probabilities. / A Dissertation submitted to the Department of Statistics in partial fulfillment of the requirements for the degree of Doctor of Philosophy. / Fall Semester, 2005. / September 9, 2005. / Kernel Density Estimate, Coronary Heart Disease, CART, Relative Risk Trees, Tree Comparison / Includes bibliographical references. / Daniel McGee, Sr., Professor Directing Dissertation; Myra Hurt, Outside Committee Member; Fred Huffer, Committee Member; Xufeng Niu, Committee Member.
ContributorsFranks, Billy J. (authoraut), McGee, Daniel (professor directing dissertation), Hurt, Myra (outside committee member), Huffer, Fred (committee member), Niu, Xufeng (committee member), Department of Statistics (degree granting department), Florida State University (degree granting institution)
PublisherFlorida State University, Florida State University
Source SetsFlorida State University
LanguageEnglish, English
Detected LanguageEnglish
TypeText, text
Format1 online resource, computer, application/pdf
RightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). The copyright in theses and dissertations completed at Florida State University is held by the students who author them.

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