This thesis describes the work performed by the author during PhD studies at FSU. The first two chapters present the summary of the studies done trying to accomplish the first total
synthesis of aldingenin B - a natural product first isolated in 2003. While our studies were ongoing, some additional information on the structure of the natural product emerged, therefore
our studies and their relationship with the literature available up to 2015 are discussed in detail. Chapters 3 through 6 represent the main topic of the thesis. They focus on the studies
directed towards the development of the efficient synthesis of ent-progesterone - a potential drug candidate for the treatment of traumatic brain injury. Chapter 3 introduces the problem
and the necessity for such synthesis and reviews the literature relevant to the topic. Chapter 4 presents an improved synthesis of rac-progesterone - an important step in the synthesis of
ent-progesterone. Chapter 5 compares the efficiency of the two approaches: an old one and the improved route. / A Dissertation submitted to the Department of Chemistry and Biochemistry in partial fulfillment of the Doctor of Philosophy. / Spring Semester 2015. / April 29, 2015. / aldingenin B, benzylation, ent-progesterone, process improvement, progesterone, total synthesis / Includes bibliographical references. / Gregory B. Dudley, Professor Directing Dissertation; John Telotte, University Representative; Tyler McQuade, Committee Member; Sourav Saha, Committee
Member; Michael Shatruk, Committee Member.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_291337 |
| Contributors | Slegeris, Rimantas (authoraut), Dudley, Gregory B. (professor directing dissertation), Telotte, John C. (university representative), McQuade, D. Tyler (David Tyler) (committee member), Saha, Sourav (committee member), Shatruk, Mykhailo (committee member), Florida State University (degree granting institution), College of Arts and Sciences (degree granting college), Department of Chemistry and Biochemistry (degree granting department) |
| Publisher | Florida State University |
| Source Sets | Florida State University |
| Language | English, English |
| Detected Language | English |
| Type | Text, text |
| Format | 1 online resource (194 pages), computer, application/pdf |
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