The purpose of this investigation was to determine the biochemical and physiological responses of the ischemic diabetic rat heart as left ventricular peak systolic pressure declined to 75% and 50% of baseline. In addition, this study assessed the influence of iodoacetate in non-diabetic and diabetic animals. The results show that diabetic and iodoacetate-treated hearts reached the selected declines in pressure significantly faster (p < .05) than non-diabetic hearts. Significantly lower (p < .05) myocardial ATP levels were found in the diabetic and iodoacetate-treated rat hearts indicating that the relative lack of anaerobically-derived ATP hastened the reduction in pressure. Myocardial glycogen utilization was significantly greater (p < .05) in diabetic hearts. However, intramuscular lactate indicative of anaerobic ATP production remained relatively lower than non-diabetic values. The results strongly suggest that the relative decrease in anaerobically-derived ATP is responsible for the rapid decline in left ventricular peak systolic pressure associated with the diabetic rat heart. / Source: Dissertation Abstracts International, Volume: 44-06, Section: B, page: 1732. / Thesis (Ph.D.)--The Florida State University, 1983.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_75116 |
| Contributors | KILGOUR, ROBERT DAVY., Florida State University |
| Source Sets | Florida State University |
| Detected Language | English |
| Type | Text |
| Format | 86 p. |
| Rights | On campus use only. |
| Relation | Dissertation Abstracts International |
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