Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies

Description

The human genome encodes information that instructs human development, physiology, medicine, and evolution. Massive amount of genomic data has generated an ever-growing pool of hypothesis. Genome editing, broadly defined as targeted changes to the genome, posits to deliver the promise of genomic revolution to transform basic science and personalized medicine. This thesis aims to contribute to this scientific endeavor with a particular focus on the development of effective human genome engineering tools.

Links & Downloads

1. Yang, Luhan. 2013. Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies. Doctoral dissertation, Harvard University.
2. http://dissertations.umi.com/gsas.harvard:11117
3. http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181072

Tags

Biomedical engineering

Biochemistry

CRISPR/cas

gene therapy

human genome engineering

TALE

targeted nucleases

Additional Fields

Identifer	oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11181072
Date	18 October 2013
Creators	Yang, Luhan
Contributors	Church, George McDonald
Publisher	Harvard University
Source Sets	Harvard University
Language	en_US
Detected Language	English
Type	Thesis or Dissertation
Rights	open