Many human traits and diseases have a polygenic architecture, where phenotype is partially determined by variation in many genes. These complex traits or diseases can be highly heritable and genome-wide association studies (GWAS) have been relatively successful in the identification of associated variants. However, these variants typically do not account for most of the heritability and thus, the genetic architecture remains uncertain.
| Identifer | oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/12274191 |
| Date | 04 December 2014 |
| Creators | Chan, Ying Leong |
| Contributors | Hirschhorn, Joel Naom |
| Publisher | Harvard University |
| Source Sets | Harvard University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Rights | open |
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