Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas

Description

With the lighting speed revolution of technologies in chemistry and biology, increasing number of proteins which eluded scientists' efforts to block them before and were labeled as `undruggable', were successfully targeted with small molecule inhibitors. During the past five years, I have been working on figuring out the path to inhibit two elusive cancer targets: Her3 and KRas. / Chemistry and Chemical Biology

Links & Downloads

1. Xie, Ting. 2014. Targeting `Undruggable' Cancer Proteins with Irreversible Small Molecule Inhibitors: Her3 and KRas. Doctoral dissertation, Harvard University.
2. http://dissertations.umi.com/gsas.harvard:11384
3. http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274197

Tags

Chemistry

Biology

Biochemistry

Her3

KRas

Additional Fields

Identifer	oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/12274197
Date	January 2014
Creators	Xie, Ting
Contributors	Gray, Nathanael Schiander
Publisher	Harvard University
Source Sets	Harvard University
Language	en_US
Detected Language	English
Type	Thesis or Dissertation
Rights	closed access