<p> Evidence of gene conversion and inter=allelic complementation
from earlier work on the pdx-1 locus of Neurospora crassa suggested
that a more detailed analysis of this locus should lead to a better
understanding of these genetic phenomenao The work described in this
thesis is concerned with the derivation of complementation maps for
seven alleles of the pdx-1 locus, and with a study of recombination
between these alleles through the isolation of prototrophs from suitably marked inter-allelic crosses together with the isolation of asci
including those exhibiting the phenomenon of gene conversione In
additioni the relationships betwean the pdx-1 alleles and a gene,
en-pdx-1, affecting the excretion of a pigment into the medium on
which the pdx-1 strains were grown were studied. The effect of
desoxypyridoxine hydrochloride 9 and the extent to which the pdx-1
mutants respond to various normal forms of the vitamin, were also
studied. </p> / Thesis / Doctor of Philosophy (PhD)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/19959 |
| Date | 08 1900 |
| Creators | Radford, Alan |
| Contributors | Threlkeld, S. F. H., Biology |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
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