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Oleanic acid: its isolation and derivatisation to potential antimicrobial compounds

A thesis submitted to the Cape Peninsula University of Technology in
fulfilment of the requirements for the
Department of Chemistry January 2007 / An increasing number of natural products possessing the oleanolic acid moiety
have been shown to demonstrate a wide spectrum of biological activity.
This thesis deals with the extraction and isolation of oleanolic acid from
Syzigium aromaticum and the examination of its stereochemistry and crystal
structure by X-ray diffraction.
The synthetic routes used for converting functional groups on the oleanolic acid
molecule to afford derivatives are described in Chapter 5.
Oleanolic acid and its derivatives were evaluated for antimicrobial activity.
Three different procedures viz. Kirby-Bauer, Broth dilution and Tetrazolium salt
chemosensitivity were used. Acceptable results were obtained from the last
method and these were used to arrive at conclusions regarding this study.
Date January 2007
CreatorsWicht, Merril Margaret
ContributorsHugo, V.I., Prof
PublisherCape Peninsula University of Technology
Source SetsSouth African National ETD Portal
Detected LanguageEnglish

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