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Inclusion behaviour of related organic host compounds

Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2007 / The inclusion behaviour of the two host compounds, 9-(4-methoxyphenyl)-9Hxanthen-
9-o1 (A1)• and 9-(4-methylphenyl)-9H-xanthen-9-o1 (A10) were
investigated. These host compounds are large, bulky, rigid and they contain
functionalities that allow them to selectively interact with other molecules,
such as the guests in this work. The host molecules form inclusion complexes
with small organic guest molecules. The host•••guest interactions are the
interesting focus of this study.

The host A1 included the guests: cyclohexane, 1,4-dioxane and N,N-dimethylformamide.
Kinetics of desolvation were studied for the 1,4-dioxane
and N,N-dimethylformamide compounds. Guest-exchange reactions were
performed. The hostA1 was also used in the separation of 1, 4-dioxane and

The host A10 included the guests; benzene, 1,4-dioxane, cyclohexane,
cyclohexanone, N,N-dimethylacetamide and N,N-dimethylformamide.
Kinetics of desolvation were studied for the benzene and cyclohexane
compounds. The host A10 was used in the separation of the following pairs
of guests: benzene and 1,4-dioxane; N,N-dimethylformamide and N,Ndimethylacetamide.

The structures of the compounds were elucidated using single crystal X-ray
diffraction. Thermal analysis was performed in order to determine the thermal stabilities of the complexes, including techniques such as thermogravimetry,
differential scanning calorimetry and melting point measurement. The
reactions in the guest exchange experiments were monitored using differential
scanning calorimetry.

Competition experiments were performed to determine the selectivity of a host
for a series of related guests. These experiments were conducted between
pairs of guests.
Date January 2007
CreatorsFaleni, Nobathembu
ContributorsJacobs, Ayesha, Dr
PublisherCape Peninsula University of Technology
Source SetsSouth African National ETD Portal
Detected LanguageEnglish

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