Thesis (DMed (Obstetrics and Gynaecology))--Stellenbosch University, 2008. / Chapter 1 presents a literature study on the diagnostic debate of PCOS. The literature study
includes a discussion of the recent Rotterdam consensus statement regarding the diagnosis of
PCOS. This is followed by a discussion on the essential work-up of the patient presenting with
PCOS. Finally, chapter 1 presents a discussion on the complexity of the different variations in
women presenting with PCOS.
Chapter 2 is a literature review on ovulation induction methods in patients who present with
PCOS. This literature study puts special emphasis on the different available methods used for
ovulation induction in women with PCOS and the profounding effect weight loss will have in
managing these patients. This chapter also addresses the use of newer agents, like aromatase
inhibitors (Letrozole), and the current role of each of these agents in ovulation induction protocols.
Chapter 3 is a literature overview on the effect of Metformin in Clomiphene-resistant PCOS
women. The inclusion criteria of this review was all prospective randomized trials where Metformin
was added for ovulation in the Clomiphene-resistant PCOS patient. The data is presented as a metaanalysis.
Chapter 4 is a prospective randomise control trial to evaluate the benefit of metformin if added to
Clomiphene in a primary ovulation induction protocol in comparison to Clomiphene alone. This
chapter also evaluates all factors influencing ovulation outcome. Finally in the discussion section all
the recent studies published addressing this topic were reviewed.
Chapter 5 is a literature review to evaluate the classification systems for semen parameters and the
in vivo fertility potential. This data is also used to establish fertility/subfertility thresholds for semen
parameters.
This chapter also presents the results of a prospective and retrospective study of the semen analysis
of the partners of women with PCOS. We believe that this population presents the best reference
group to study the semen profile of the general male population.
Chapter 6 is a summary of the results of these studies and serves as an evidence based approach for
ovulation induction in women with PCOS.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:sun/oai:scholar.sun.ac.za:10019.1/4076 |
| Date | 12 1900 |
| Creators | Siebert, T. I. |
| Contributors | Kruger, T. F., Stellenbosch University. Faculty of Health Sciences. Dept. of Obstetrics and Gynaecology. |
| Publisher | Stellenbosch : Stellenbosch University |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Rights | Stellenbosch University |
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