N,N-Dimethylformamide (DMF) is a well-known chemical entity that is extensively used for pharmaceutical,
biomedical and chemical applications. Previous research identified the need for the development
of an effective dosage form for the systemic delivery of DMF due to its unique antiviral properties. For
purposes of quality control and evaluation during pharmaceutical product development, development
of an analytical method was required. A gas chromatographic (GC) method was developed with a
flame-ionization detector (FID) on a carbowax packed glass column. 2-Methoxyethanol was used as
internal standard. The analytical method proved to be capable of separating DMF and 2-methoxyethanol
adequately within a relatively short runtime of 2.5 min. The analytical method described was primarily
developed for use in dissolution studies of DMF containing delivery systems. Various physicochemical
properties of candidate internal standard materials were correlated with the observed retention
times of these compounds. The best correlation (r2 ΒΌ 0.8077) was obtained between the boiling
point and the retention time of the compounds for the current application. The boiling point of an
internal standard candidate material may therefore be useful in predicting the retention time of that
compound under similar conditions.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:tut/oai:encore.tut.ac.za:d1000865 |
| Date | 25 September 2007 |
| Creators | Olivier, EI, Du Toit, D, Hamman, JH |
| Publisher | Pharmazie |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Text |
| Format | |
| Rights | Pharmazie |
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