Includes bibliography. / Despite major advances over the last two decades with the management of patients with Zollinger-Ellison syndrome (ZES), unanswered questions remain concerning the natural history of the disease, the impact of new diagnostics modalities on cure rates, and the role of surgery in the era of modem medical therapies. The aims of the thesis are to (i) analyse the database of 40 ZES patients treated at Groote Schuur Hospital (GSH) over two decades, with special reference to the impact of various surgical strategies on outcome, (ii) investigate a possible correlation between biological tissue marker expression and tumour behaviour, (iii) study the effect of somatostatin receptor scintigraphy (SRS) on surgical cure rates, and (iv) assess the efficacy and safety of a new proton pump inhibitor (pantoprazole) in controlling acid hypersecretion.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/10762 |
| Date | January 2000 |
| Creators | Radebold, Klaus |
| Contributors | Bornman, PC |
| Publisher | University of Cape Town, Faculty of Health Sciences, Department of Surgery |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Doctoral Thesis, Doctoral, PhD |
| Format | application/pdf |
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