Includes abstract. / Includes bibliographical references (leaves 170-210). / Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little is known about the effect of HIV-infection on function and phenotype of T cell responses to mycobacterial antigens in children. This study compares both CD4 and CD8 T cell cytokine expression and memory phenotype in children, following in vitro stimulation with mycobacterial antigens, also contained in novel anti-TB vaccines that are currently undergoing clinical trials.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/11689 |
| Date | January 2011 |
| Creators | Tena-Coki, Nontobeko Gwendoline |
| Contributors | Hanekom, Willem, Scriba, Thomas, Kampmann, Beate |
| Publisher | University of Cape Town, Faculty of Health Sciences, Institute of Infectious Disease and Molecular Medicine |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Doctoral Thesis, Doctoral, PhD |
| Format | application/pdf |
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