Includes abstract. / Includes bibliographical references (leaves 81-95). / This study focuses on newly synthesized polyphenolic compounds which were expected to be antioxidants in vivo. Antioxidants are compounds which at low concentrations can prevent or reduce the deleterious effects caused by reactive oxygen species (ROS) induced by UVA exposure of the skin. This study focuses on developing methods required to measure the effects of these synthesized compounds in ultraviolet radiation-exposed cultured skin cells. Biocatalytic synthesis of polyphenolic compounds was carried out using isolated enzymes, tyrosinase from Agaricus biosporus, and laccase from Trametes pubescens to produce oxidized oligomeric products.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/12126 |
| Date | January 2009 |
| Creators | Zwane, Eunice Nonhlanhla |
| Contributors | Burton, Stephanie Gail |
| Publisher | University of Cape Town, Faculty of Engineering and the Built Environment, Centre for Bioprocess Engineering Research |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Master Thesis, Masters, MSc |
| Format | application/pdf |
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