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Network-based approach for post genome-wide association study analysis in admixed populations

Includes abstract. / Includes bibliographical references. / In this project, we review some existing pathway-based approaches for GWA study analyses, by exploring different implemented methods for combining effects of multiple modest genetic variants at gene and pathway levels. We then propose a graph-based method, ancGWAS, that incorporates the signal from GWA study, and the locus-specific ancestry into the human protein-protein interaction (PPI) network to identify significant sub-networks or pathways associated with the trait of interest. This network-based method applies centrality measures within linkage disequilibrium (LD) on the network to search for pathways and applies a scoring summary statistic on the resulting pathways to identify the most enriched pathways associated with complex diseases.
Date January 2014
CreatorsMbiyavanga, Mamana
ContributorsMulder, Nicola
PublisherUniversity of Cape Town, Faculty of Science, Department of Molecular and Cell Biology
Source SetsSouth African National ETD Portal
Detected LanguageEnglish
TypeMaster Thesis, Masters, MSc

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