Thesis(M Med (Haematology)) -- University of Limpopo, 2011. / BACKGROUND: Multiple myeloma (MM) is a rare age-related disorder with
increasing incidence with advancing age. It is a B-cell malignancy characterised by
monoclonal expression and accumulation of abnormal plasma cells in the bone marrow.
It comprises about 1 % of all malignant tumours worldwide and 10% of haemopoietic
neoplasms. MM accounted for 0.43% of newly diagnosed malignancies in South Africa
in 1999 and Visser et al (2009), found the incidence to be 0.00054%. Mwambakana in
2000 at Ga-Rankuwa Hospital, now known as Dr George Mukhari Hospital (DGMH),
found MM to be the commonest haematological malignancy.
No clear risk factors have been identified in this disease. The natural history of MM is
one of progressive bone destruction, refractory cytopenias and end-organ damage. The
diagnosis and staging of MM is based on different criteria and systems.
OBJECTIVES: To establish a profile of patients diagnosed with MM at DGMH from 1
January 2004 to 31 December 2009.
METHODS: We conducted a descriptive retrospective review of medical records of
patients diagnosed and treated for MM at DGMH from 2004-2009.
RESULTS: Thirty-four patients' records were found. MM was found to be present in
these patients as early as the third decade, more females than males were diagnosed and
females were surviving longer than their male counterparts. Clinical features were not
significantly different from those previously reported. The WHO 2001 diagnostic
criteria created by Durie & Salmon and the International Staging System were used
more frequently and most patients presented at an advanced stage of the disease.
|Rankapole, Ruth Khutso
|Torres, MDC Zelaya, Sedumedi, Barbara
|University of Limpopo (Medunsa Campus)
|South African National ETD Portal
|Adobe Acrobat Reader, version 6.0
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