An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.

Description

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<p align="left">Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppressor proteins p53 and pRb and to mediate ubiquitination of p53 via its interaction with Hdm2. RBBP6 is highly up regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis.</p>

Links & Downloads

1. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9063_1260173635

Tags

15N-HSQC

1H-113Cd-HSQC

Cadmium ion

Coordination

Expression

RING

Spectroscopy

Zinc ion.

Additional Fields

Identifer	oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:UWC_ETD:http%3A%2F%2Fetd.uwc.ac.za%2Findex.php%3Fmodule%3Detd%26action%3Dviewtitle%26id%3Dgen8Srv25Nme4_9063_1260173635
Date	January 2007
Creators	Mulaudzi, Takalani.
Source Sets	South African National ETD Portal
Language	English
Detected Language	English
Type	Thesis and dissertation
Format	Pdf
Coverage	ZA
Rights	Copyright: University of the Western Cape