M.Med. (Diagnostic Radiology), Faculty of Health Sciences, University of the Witwatersrand, 2011 / Pneumocystis jirovecci pneumonia (PJP) in HIV/AIDS is a significant opportunistic infection. As CD4 counts decrease, so does specificity of chest X-ray (CXR). AIM: To determine the proportion of bronchoscopically proven PJP in HIV infected adults, CD4 counts, CXR signs and compare PJP to TB. METHODS: The proportion of bronchoscopically proven PJP and co-infection was determined. Sensitivity and specificity of CXR for the diagnosis of PJP and TB, and frequency of CXR signs were determined. RESULTS: PJP was present in 26.6% and co-infection 19%. Median CD4 (13 cell/mm3) was significantly lower for PJP patients (p = 0.0089). CXR sensitivity for PJP was 33% and specificity was 100%. Bilateral, multilobar and diffuse disease, bronchopneumonia, nodules and cavitation overlapped for PJP and TB. Unilateral and unilobar disease indicated TB over PJP. Effusions and lymphadenpopathy were not seen with PJP. CONCLUSION: PJP makes up a quarter of indeterminate diagnoses in HIV infected adults. Sensitivity of diagnosis on CXR is low. The CXR diagnosis of TB is made more confidently, but is overcalled. In patients with low CD4 levels, a diagnosis of PJP should be considered as important as TB.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/11330 |
| Date | 21 February 2012 |
| Creators | Rubin, Grace |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
Page generated in 0.002 seconds