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A review of patterns of renal disease at Chris Hani Baragwanath Academic Hospital from1982 to 2011

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Medicine in Internal Medicine. Johannesburg, 2013 / This study reports a review of biopsy-confirmed renal pathology from Soweto
A retrospective analysis was conducted of 1848 adult native renal biopsy reports
from Chris Hani Baragwanath Academic Hospital from 1 January 1982 to
31 December 2011.
The mean age of all patients biopsied was 33.5 ± 12.6 years and the majority of
patients (96.4%) were black. The most frequent histological findings were
secondary glomerular diseases (SGNs) (49.3%) and primary glomerular diseases
(PGNs) (39.7%). SGNs increased, while PGNs decreased over time (p<0.001).
The main contributors to SGN were lupus nephritis (31.0%) and HIV associated
nephropathy (HIVAN) (13.3%) while for PGN it was focal segmental
glomerulosclerosis (FSGS) (29.6%). HIV positive biopsies constituted 19.7% of all
biopsies with a dominant diagnosis of HIVAN (32.7%).
Changing patterns of renal disease are evident in the data. The increased SGNs
likely reflect the influence of renal pathology secondary to HIV and lupus nephritis.
Date January 2014
CreatorsVermeulen, Alda
Source SetsSouth African National ETD Portal
Detected LanguageEnglish
Formatapplication/pdf, application/pdf

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