A Thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand,
Johannesburg, in fulfilment of the requirements for the degree
of
Doctor of Philosophy / Pterygium, a wing-shaped fibrovascular growth of the conjunctiva onto the cornea, can
impair vision and be cosmetically unacceptable. Its frequency varies in Africa and postsurgical
recurrence in blacks may be high. Determinants of pterygium occurrence and
recurrence in rural Africans are not known. This study aimed to establish the determinants
of pterygium occurrence and recurrence in rural blacks.
The case controlled study comprised 230 patients and 157 controls. Interviews and eye
examination were conducted; however, data from 150 patients and 150 controls were
analyzed as pre-calculated. Families of 51 cases and 50 controls were studied. Surgery was
done on 200 eligible patients. Those who experienced post-surgical recurrence were subclassified
as cases and those who did not, controls. Immunohistochemistry was done on 59
pterygium sections and 7 controls.
Family history of pterygium was present in 46 cases (30.6%) of 150, and 15 controls
(10%) of 150; Odds ratio (OR) =3.93; p <0.01. Traditional eye medication was used by 79
cases (52.6%) of 150, and 60 controls (40%) of 150; OR =2.03; p <0.01. The tear film was
unstable in 10 cases (6.6%) of 150, and 26 controls (17.3%) of 150; OR =0.30; p <0.01.
Groups of 3-5 individuals per household were pterygium-affected in 36 pterygium families
(70.5%) of 51 vs. 1 control (2%) of 50. After surgery, only 190 patients completed followup
for a minimum duration of 6 months, and 52 (27.4%) experienced post-surgical
recurrence. Of the 52 cases, 21 (40%) had grade 2 pterygia v. 8 post-surgical controls
having grade 2 pterygia (6%) of 138; OR =9.1; p <0.01. The limbal basal epithelium
expressed p53 in 11 pterygia (18.6%) of 59 v. 5 controls (71.4%) of 7; p <0.01. It
expressed matrixmetalloproteinase-1 (MMP1) in 14 pterygia (23.7%) of 59 v. 5 controls
(71.4%) of 7; p =0.02. MMP2 and MMP3 were detected in 16 cases (27.1%) of 59 v. 5
controls (71.4%) of 7; p =0.03.
Pterygium occurred in families and was associated with traditional eye medication.
Pterygium occurrence was not associated with unstable tear film, p53, and MMPs. Postsurgical
recurrence was connected to grade 2 pterygia.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/18673 |
| Date | 16 September 2015 |
| Creators | Anguria, Peter |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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