The role of nucleophosmin fusion sequences in the oncogenic activation of the (2;5) translocation protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)

Description

A thesis submitted to the Faculty of Science, University of the
Witwatersrand, Johannesburg, South Africa, in fulfillment of the requirements
for the degree of Doctor of Philosophy.
Johannesburg, 1996 / The NPM-ALK fusion gene, formed by the t(2;5)(p23;q35) in non-Hodgkin's
lymphoma encodes a 75kDa hybrid protein that contains the amino-terminal
118 amino acid residues of the nucleolar phosphoprotein nucleophosmin
(NPM) joined to the entire cytoptasmic portion of the receptor tyrosine
kinase, anaplastic lymphoma kinase (ALK). The transforming ability of NPM-ALK
is demonstrated and it is shown that oncogenesis by the chimaeric
protein requires the activation of its kinase function as a result of
oligomerisation mediated by the NPM segment. [Abbreviated Abstract. Open document to view full version]

Links & Downloads

1. Bischof, Daniela (2016) The role of nucleophosmin fusion sequences in the oncogenic activation of the (2;5) translocation protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), University of Witwatersrand, Johannesburg, <http://wiredspace.wits.ac.za/handle/10539/20829>
2. http://hdl.handle.net/10539/20829

Tags

Clinical biochemistry

Pathology

Additional Fields

Identifer	oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/20829
Date	January 1996
Creators	Bischof, Daniela
Source Sets	South African National ETD Portal
Language	English
Detected Language	English
Type	Thesis
Format	Online resource (126 leaves), application/pdf