A dissertation submitted to the Faculty of Science, in partial fulfilment of the requirements for the award of Master of Science degree, University of the Witwatersrand, Johannesburg, 2018 / Three mixed-ligand metal-metal bonded complexes containing one unsymmetrical anionic bridging ligand were successfully synthesized and characterized as to their electrochemical and spectroscopic properties. The investigated mono-substituted diruthenium complexes have the general formula, Ru2(OAc)3(L)Cl, where OAc = acetate anion and L = anilinopyridinate bridging ligand (ap, 2-Meap, 2-Fap). UV/Visible spectroscopy studies reveal that the investigated diruthenium complexes exist in the forms Ru2(OAc)3(L)Cl and [Ru2(OAc)3(L)]+ in solution. The two forms are observed as a split band in the 500 – 700 nm visible region. A collapse of one band is seen upon reaction of the complexes with excess halide (Cl-, Br-) indicating an equilibrium shift towards the neutral species in solution, whereas a reaction with AgBF4 precipitates the chloride as the AgCl salt, leaving only the cationic species in solution. Electrochemical characterization of the mixed-ligand diruthenium complexes conclusively reveals a stable Ru25+ oxidation state in all three complexes. Upon an applied potential in a non-coordinating solvent, each complex undergoes a reversible one-electron oxidation and reduction process accessing the Ru26+, and Ru24+ oxidation states respectively. The treatment of human breast adenocarcinoma MCF-7 cells with these water-soluble complexes results in a less than 50 % cell survival. This demonstrates significance of solubility in the development of metallodrugs for cancer treatment. / XL2018
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/24928 |
| Date | January 2018 |
| Creators | Mashiloane, Karabo |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | Online resource (xii, 85 leaves), application/pdf, application/pdf |
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