MPH, Faculty of Health Sciences, University of the Witwatersrand / Background: The increase use of highly active antiretroviral therapy (HAART)
among patients with HIV infection and AIDS has led to increasing reports of
metabolic abnormalities such as diabetes mellitus, hypertension, dyslipidaemia and
obesity. Therefore, it is important to explore the burden of these diseases among
HIV infected patients.
Objectives: To determine the burden of metabolic diseases (hypertension, diabetes,
obesity and dyslipidaemia) in patients attending HIV clinic at the Charlotte Maxeke
Johannesburg Academic Hospital (JHBH).
Methodology: It was a cross-sectional study. The study population included patients
attending JHBH HIV clinic and on HAART for more than one year. A sample size of
304 patients, including 237 females and 67 males partook in this study.
Anthropometric measurements were taken from patients and blood samples of these
patients were sent to laboratory for lipograms, HbA1c, random glucose, CD4
lymphocytes counts as well as HIV viral load testing. The data was analysed with
standard statistical software Epi-info version 6.0. Both descriptive and analytical
statistics was used.
Results: The prevalence of metabolic syndrome according to the IDF was 20.4 %;
obesity (BMI 30 kg/m2) was 16.8% and patients that were overweight (BMI > 25
kg/m2 and BMI < 29.9 kg/m2) was 28.6%; hypercholesterolemia (TC 5.0 mmol/l) =
35.5%; HDL< 1.29 mmol\L in females was 58% and HDL <1.04 mmol/l in males was
36%; elevated triglycerides 1.7 mmol/l was 30% and only 16% was classified as
being hypertensive (BP 140/90 mmHg and / or on Hypertensive medication). The
majority of the patients (86.2%) had a CD4 lymphocyte count 200 X 106 cells/l
and 84% of patients had less than detectable limits for viral loads (VL< 40 copies /
μl), which has been reported as optimum levels for metabolic diseases in HAART
recipients.
Conclusion: These results clearly indicate that there is a growing burden of
metabolic diseases among HIV patients on HAART attending the Johannesburg
hospital HIV clinic. The current study also indicates that the metabolic disturbances
are more frequent in women than in men, except for hypertension.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/8833 |
| Date | 15 October 2010 |
| Creators | Julius, Henry Patrick |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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