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Vliv klíštěcích cystatinů na TLR - indukovanou maturaci myeloidních dendritických buněk / The effect of tick cystatins on TLR - induced maturation of myeloid dendritic cells

Tick saliva contains a lot of molecules with antihemostatic and immunosupressive effects.The goal of this thesis is to test the effects of tick salivary cystatins from I.ricinus and I.scapularis on TLR - induced maturation of bone-marrow derived dendritic cells and production of chosen cytokines. Over all, the supressive effect of tick cystatins was observed in relation to TLR-induced maturation of DC. In addition, cystatins enhanced production of IL-10 and attenuated induction of IL-12 cytokines.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:173159
Date January 2014
CreatorsNERADOVÁ, Hana
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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